First-Step Mutations during Adaptation Restore the Expression of Hundreds of Genes.

Mol Biol Evol · 2016 · PMC4693981 · PMID 26500250

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a slight trendno p-value reported

Accordingly, we have examined RNAP efficiency and found a slight trend toward higher rates of transcriptional efficiency for two of the three mutations in codon 572 of rpoB.

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highly significantno p-value reported

For the three mutants we observed a highly significant negative correlation, with slopes of −0.738 for I572F , −0.639 for I572L, and −0.731 for I572N ( fig. 4 A–C ).

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