Bearing in mind the crucial role for PRK1 and PRK2 in the epigenetic regulation of events associated with prostate tumour progression/metastasis [ 47 , 55 ], our discovery of the propensity of TPα/TPβ to induce PRK1/PRK2-mediated chromatin remodelling and neoplastic responses in prostate cells is highly significant, and highlights the potential for TPα and/or TPβ as a therapeutic target in the treatment of prostate cancer including CRPC and potentially in other cancers in which aberrant TP:PRK1 and/or PRK2 signalling is implicated.
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Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer.
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