A poxviral-based cancer vaccine the transcription factor twist inhibits primary tumor growth and metastases in a model of metastatic breast cancer and improves survival in a spontaneous prostate cancer model.

Oncotarget · 2015 · PMC4695054 · PMID 26317648

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highly significantno p-value reported

The ability of MVA-TWIST/TRICOM to induce antigen cascade is highly significant as it has been suggested that the ability to stimulate immune responses to cascade antigens correlates better with antitumor efficacy than the ability to induce an immune response to the antigen being delivered by the vaccine [ 44 , 45 ].

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