To explore ATAD2 alterations in detail for endometrial cancer, putative copy-number alterations (GISTIC-based analysis [ 17 ]), showed a highly significant correlation of increased copy-number levels and mRNA expression of ATAD2 for endometrial cancer, confirming previous findings that ATAD2 amplification leads to higher expression of ATAD2 ( Supplementary Figure S1A ).
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ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma.
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