The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition.

Oncotarget · 2015 · PMC4695128 · PMID 26156019

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highly significantno p-value reported

It is noteworthy that the relevance of these relationships to human MPM could be highly significant for the development of new therapeutic approaches for this cancer, which at present is neglected.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.