Interestingly, enhancing THBS2 expression in the MDA-MB-231 cell line partially rescued metastasis upon AXL inhibition in spite of the fact that THBS2 overexpression only provided a positive trend toward metastasis in these cells ( Figures 5 G, S5 I, and S5J).
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Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.
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