Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis.

PLoS One · 2015 · PMC4696815 · PMID 26717306

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highly significantno p-value reported

The highly significant preferential binding of AMD sera by ELISA conclusively confirmed that HSPA8, HSPA9, HSPB4/CRYAA, ANXA5, and S100A9 are specific AAb targets in AMD ( Fig 3 ): anti-HSPA8 autoreactivity was 0.54±0.04 in AMD samples (mean±SE) and 0.25±0.02 in control samples (p = 0.000003, 2-sided test for unequal var

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