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Drug utilisation and off-label use of medications in anaesthesia in surgical wards of a teaching hospital.

Indian J Anaesth · 2015 · PMC4697244 · PMID 26755837

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an increasing trendno p-value reported
There was an increasing trend in the occurrence of adverse events with increasing instances of off-label drugs encountered per patient e.g., 33.7% of patients prescribed one off-label drug each had adverse events whereas 66.6% of patients prescribed four off- label drugs had adverse events.

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