Barely Significant
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High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.

Biophys J · 2015 · PMC4699860 · PMID 26682817

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highly significantno p-value reported
The role of HVR in K-Ras4B-induced oncogenesis remains controversial, with reports supporting both highly significant and more subtle effects of HVR mutations on K-Ras4B G12V-dependent cancer transformation ( 18 , 53 ).

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