Dual modulation of Ras-Mnk and PI3K-AKT-mTOR pathways: A Novel c-FLIP inhibitory mechanism of 3-AWA mediated translational attenuation through dephosphorylation of eIF4E.

Sci Rep · 2016 · PMC4700468 · PMID 26728896

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extremely significantno p-value reported

The de-phosphorylation of eIF4E by 3-AWA resulted in a sharp downregulation of c-FLIP along with upregulation of FAS; although the effects were less in NIH-3T3 but were extremely significant in PC-3 cells ( Fig. 2E ).

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