Serum Biomarkers Associated with Clinical Outcomes Fail to Predict Brain Metastases in Patients with Stage IV Non-Small Cell Lung Cancers.

PLoS One · 2016 · PMC4701719 · PMID 26730601

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

highly significantno p-value reported

While there was a trend toward an association between high baseline HE4 and increased subsequent development of brain metastases (p = 0.07), such a biomarker cannot be recommended for clinical use without independent validation of a highly significant association.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.