Barely Significant
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Normal and Fibrotic Rat Livers Demonstrate Shear Strain Softening and Compression Stiffening: A Model for Soft Tissue Mechanics.

PLoS One · 2016 · PMC4703410 · PMID 26735954

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may be significantno p-value reported
Glycosaminoglycans carry densely packed negative charges and as a result there may be significant osmotic shifts associated with compression, leading to stiffening.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.