CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial.

Although, in our study, the gene-diet interaction term between the SNP and dietary intervention on T2D incidence was borderline significant (P = 0.052) at P < 0.05, taking into account that we can consider a P < 0.1 for the significance level of the interaction term as suggestive of interaction when some criteria of reliability are accomplished [ 45 ], our study fulfill these criteria to avoid false negative results and we considered this significance level (P < 0.1) to conduct the stratified analyses by MedDiet intervention groups.

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