RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1.

The effect of controlled RNA turnover on gene expression can be extremely significant: for example, some studies have shown that 40–50% of changes in gene expression occur at the level of RNA stability ( 1 ).

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