Indeed, even the biggest cluster—containing 17 DGCs with 5 harboring a basal dendrite—failed to reach significance even if the experiment-wise α value is relaxed to 0.05 ( p = 0.054; threshold p value for α = 0.001, 5.41 × 10 −6 ; for α = 0.05, 2.60 × 10 −4 ).
The significant shift away from progenitors in animals exposed to SE was mirrored by a nonsignificant trend in the proportion of mature granule cells produced [ p = 0.065, SE mice ( n = 12) vs control mice ( n = 5), Mann–Whitney RST] and a significant increase in the percentage of clusters that were “fully differentiated,” meaning the clusters contained only granule cells and astrocytes, and were devoid of progenitors [ p = 0.010, SE mice ( n = 12) vs control mice ( n = 5), two-tailed t test).