Barely Significant
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Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study group.

Mol Genet Genomic Med · 2016 · PMC4707032 · PMID 26788538

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highly significantno p-value reported
However, with regard to the symptomatic individual, these mutations should be considered highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.