Myelin Basic Protein-Induced Production of Tumor Necrosis Factor-α and Interleukin-6, and Presentation of the Immunodominant Peptide MBP85-99 by B Cells from Patients with Relapsing-Remitting Multiple Sclerosis.

IL-10-producing B cells from healthy donors, however, presented MBP85-99 as efficiently as the background B-cell population ( Fig 5D ), whereas IL-10-producing B cells from RRMS patients showed diminished capacity to present the peptide—both in comparison to the patients’ B-cell population as a whole and, with borderline significance, to IL-10-producing B cells from healthy donors.

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