The N/P = 14 and 21 formulations of pMAT- b -AEMA-2 and N/P = 7 formulation of pMAT- b -AEMA-3 were found to be statistically similar to the positive control jetPEI. While none of the pMAT- b -AEMA-2 formulations nor any of the positive controls differed statistically from each other when compared to the cells-only control, an interesting trend appeared in the other samples: both the shortest and longest MAT polymers showed decreased uptake values with an increase in N/P ratio with U87 cells.
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Trehalose-Based Block Copolycations Promote Polyplex Stabilization for Lyophilization and in Vivo pDNA Delivery.
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