Dual Endothelin Receptor Blockade Abrogates Right Ventricular Remodeling and Biventricular Fibrosis in Isolated Elevated Right Ventricular Afterload.

PLoS One · 2016 · PMC4713098 · PMID 26765263

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a decreasing trendno p-value reported

We believe that following ET-1 receptor blockade, circulating ET-1 levels significantly increase while CTGF protein levels and TGF-β1 mRNA expression, thought to act upstream of ET-1, shows a decreasing trend.

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