Importantly, knockdown of CB1 as well as CB2 resulted in highly significant abrogation of proapoptotic effects upon treatment with THC (see Additional file 9 : Figure S9), supporting the finding of a direct role of either of the cannabinoid receptors in induction of apoptosis in acute leukemia models.
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Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns.
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