Semi-Mechanism-Based Population Pharmacokinetic Modeling of the Hedgehog Pathway Inhibitor Vismodegib.

CPT Pharmacometrics Syst Pharmacol · 2015 · PMC4716579 · PMID 26783504

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an obvious trendno p-value reported

The observed data did not show an obvious trend between unbound vismodegib concentration and AAG, which might be due to that both trough and nontrough unbound data were included, and also the limited data with higher AAG level ( Figure 2 ).

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