Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.

In contrast, the global therapeutic effect over time of ADX88178 at the doses of 30 and 60 mg/kg was almost ( P = 0.0853) or highly significant ( P = 0.0095), respectively ( Fig. 2A and Table S2 ).

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