Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways.

In both cohorts there was an increased percentage of smokers in the affected group ( Figure 1a and b ) and the association result from the meta-analysis was highly significant ( P =0.009; Supplementary Figure1A ).

also in 132,142 other papers