Overexpression of ATF4 in HUVECs resulted in a highly significant up-regulation in CSE transcription ( Fig. 3 A ), suggesting that in endothelial cells, as in mouse embryonic fibroblasts, CSE is a transcriptional target of ATF4.
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Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling.
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