Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens.

In our studies, all three adjuvants with the ability to induce highly significant protection against TB, induced phenotypic profiles very similar to what was observed previously in humans with a substantial proportion of IL-2/TNF-α co-producers, most pronounced in the CAF01 group where app. 50% of the cells were of this phenotype.

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