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Spatiotemporal Cluster Patterns of Hand, Foot, and Mouth Disease at the County Level in Mainland China, 2008-2012.

PLoS One · 2016 · PMC4726594 · PMID 26809151

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an increasing trendno p-value reported
Considering that HFMD is showing an increasing trend, more effort is required for its prevention and control.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.