The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury.

Front Mol Neurosci · 2016 · PMC4727241 · PMID 26858599

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These data are highly significant to AD because: (1) mitochondrial dysfunction (Selfridge et al., 2013 ) and calpain-activation are linked to AD (Saito et al., 1993 ; Ferreira and Bigio, 2011 ); and (2) calpain-dependent Tau fragments are detected in the brains of AD patients (Ferreira and Bigio, 2011 ; Garg et al., 2011 ).

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