Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease.

80 In addition, the Towards a Revolution in COPD Health study showed a 17% relative reduction in mortality for more than 3 years for patients receiving combined salmeterol and fluticasone propionate, although this just failed to reach significance. 81 Blood eosinophil count is a promising biomarker of the response to ICSs in COPD and could potentially be used to stratify patients for different exacerbation rate reduction strategies. 82 Corticosteroid suppression of many inflammatory genes requires recruitment of histone deacetylases (HDACs) to the gene activation complex by the activated glucocorticoid receptor.

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