Clinical Overview of MDM2/X-Targeted Therapies.

For example, liposarcoma, which is one of the first tumors in which MDM2 inhibitors have been evaluated ( 45 ), shows highly significant tendency toward mutual exclusivity ( p -value <0.001) between overexpression of MDM2 (19%) and p53 mutation (12%) (Figure 1 A) ( 5 ).

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