Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume.

Dis Model Mech · 2016 · PMC4728330 · PMID 26563390

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highly significantno p-value reported

The total lung volume followed the same evolution, resulting in a highly significant 25.00±9.43% increase in total lung volume at 20 weeks compared to 8 weeks of age ( Fig. 1 A,C).

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