Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment.

Astrocyte and endothelial expression appears normal, while highly significant down-regulation of Oligodendrocyte genes was found in the Caudate Nucleus ( p < 0.00001, 0 d ( γ X , γ D ̄ ) = 13 . 1 ), Cingulate Cortex ( p < 0.00001, d ( γ X , γ D ̄ ) = 11 . 6 ), Hippocampus ( p < 0.0057, d ( γ X , γ D ̄ ) = 4 ), Middle Temporal Gyrus ( p < 0.0001, d ( γ X , γ D ̄ ) = 5 . 7 ), and the Temporal Pole ( p < 0.0001, d ( γ X , γ D ̄ ) = 8 . 2 ).

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