A potential mechanism contributing to cognitive dysfunction in both insulin-insensitive and insulin-insufficient disorders may be significant sustained glucocorticoid elevation [ 87 ], a sex-independent finding we previously reported in this model (200–300 % elevations in corticosterone were observed in both HFD females and males) [ 1 ].
← all excerpts
High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity.
1
—
—