Gene co-expression networks shed light into diseases of brain iron accumulation.

To validate our networks, we determined whether our NBIA-containing modules are composed of the same genes as those in publicly available caudate nucleus networks ( Oldham et al., 2008 ) and identified a highly significant overlap between these two basal ganglia networks (e.g. our brown module vs their M16C module: p = 1.38 × 10 − 22 ; our green module vs their M9C module: p = 2.69 × 10 − 166 ).

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