The Effect of Culture on Human Bone Marrow Mesenchymal Stem Cells: Focus on DNA Methylation Profiles.

Stem Cells Int · 2016 · PMC4736560 · PMID 26880970

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DNA methylation (DNAm) patterns were overlapping and maintained throughout both long-term culture and aging, and highly significant differences were observed only at specific CpG islands (CGIs), associated with promoter regions, especially in homeobox genes and genes involved in cell differentiation [ 14 ].

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