F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling.

Neutrophil extravasation and TRITC–dextran leakage in WT mice were not correlated in individual mice, although there was an overall association between extravasation and permeability, whereas the two processes in Rho-inhibited animals showed a highly significant correlation ( Fig. 1f ).

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