Perampanel for focal epilepsy: insights from early clinical experience.

Acta Neurol Scand · 2016 · PMC4738453 · PMID 26506904

Europe PMC DOI

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an increasing trendno p-value reported

In general, there has been an increasing trend away from the use of older AEDs in elderly patients, for reasons including high levels of protein binding and unfavorable pharmacokinetics.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.