Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.

Importantly, statistical significance or a trend toward significance was retained at other cut-points as well, including 1, 10 and 20% (PFS log-rank P =0.01, P =0.08 and P =0.03, respectively, and OS log-rank P =0.002, P =0.01 and P =0.11, respectively; Supplementary Fig. 3 ).

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CD4 was not statistically associated with therapy response, while a trend towards significance was detected with CD8 (Mann–Whitney's P =0.077; Supplementary Fig. 7 ), as has been previously described 18 .

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