Novel Axl-driven signaling pathway and molecular signature characterize high-grade ovarian cancer patients with poor clinical outcome.

Among these genes, the expression of four of them (DCN, FN1, MMP2, and PLAU) was significantly correlated to AXL expression (R 2 range: 0.76–0.86; p value range: 0.0048–0.00012), while that of CDH11 showed an R 2 = 0.48 but a borderline significance ( p = 0.057 ), and the expression of three of them (CXCL12, TGFB1, and ZEB2) was not correlated to AXL ( Supplementary Fig. 5 ).

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