Flagellin Encoded in Gene-Based Vector Vaccines Is a Route-Dependent Immune Adjuvant.

However, inclusion of flagellin only in the DNA vaccine prime followed by systemic or mucosal boosting with Ad-encoded Ag85B mediated a highly significant reduction in pulmonary bacterial load ( Fig 6A and 6B ), particularly following mucosal boosting (7-fold reduction in lungs compared to sham immunized mice).

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