MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression.

This analysis revealed a highly significant enrichment of microRNA triplex binding sites in all genomes analyzed ( Fig 1 ), including Homo sapiens ( Fig 1I ), Mus musculus ( Fig 1J ), Rattus norvegicus ( Fig 1N ), Caenorhabditis elegans ( Fig 1D ) and Arabidopsis thaliana ( Fig 1B ), when compared to random DNA sequences analyzed for microRNA binding sites.

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