Intracellular mGluR5 plays a critical role in neuropathic pain.

Nat Commun · 2016 · PMC4742982 · PMID 26837579

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Spinal pretreatment with the permeable mGluR5 antagonist fenobam (1–100 nmol) produced a highly significant, dose-dependent reduction of glutamate-induced pain behaviours in SNI rats, whereas pretreatment with the impermeable antagonist LY393053 (1–1,000 nmol; Fig. 5a,b ) was less effective.

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