PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications.

Of note, we observed a borderline significant decrease in phosphorylated eIF2α levels in PKR KO animals (two-way analysis of variance (ANOVA), genotype main effect P =0.05), suggesting that PKR indeed contributes to eIF2α phosphorylation status in adipose tissue, irrespective of dietary status ( Fig. 4h and Supplementary Fig. 4 ).

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