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Differences in Investigator-Initiated Trials between Japan and Other Countries: Analyses of Clinical Trials Sponsored by Academia and Government in the ClinicalTrials.gov Registry and in the Three Japanese Registries.

PLoS One · 2016 · PMC4744062 · PMID 26848574

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an increasing trendno p-value reported
Interestingly, endocrine tumor studies were particularly characterized by female-only trials for ovarian or breast cancer, which indicates an increasing trend in the development of new ovarian and breast cancer treatments in 2010.

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