Evaluation of the Therapeutic Potential of Anti-TLR4-Antibody MTS510 in Experimental Stroke and Significance of Different Routes of Application.

at the beginning of induction of MCAO had highly significant smaller infarct volumes at 48h after reperfusion than mice treated with vehicle (PBS) only or isotype control antibody (direct infarct volumes [mean±SD] : isotype control 177.4 ± 58.3 mm 3 , PBS 155.2 ± 50.4 mm 3 , TLR4mAb 86.3 ± 37.4 mm 3 ; p [PBS vs TLR4mAb] 0.0015, p [iso vs TLR4mAb] 0.0034) ( Fig 3A ).

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