KIR haplotypes are associated with late-onset type 1 diabetes in European-American families.

Full haplotypes, containing both centromeric and telomeric portions, showed marginally significant overtransmission of KIR A1 haplotypes to affected individuals ( P =0.0494).

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Given the complexity of both the HLA and KIR genetic loci, and extreme variability of both among populations, a thorough understanding of the role of KIR genes and haplotypes in T1D will require very large sample sets, where individual subsets are large enough to uncover potential highly significant results.

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