The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.

Cell Calcium · 2016 · PMC4751975 · PMID 26769314

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may be significantno p-value reported

We suggest that there may be significant overlap, and therefore functional redundancy, between two pore channel subtypes ( Tpcn1 and Tpcn2 ), allowing NAADP-dependent actions to persist.

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