A Comparative Study of Variables Influencing Ischemic Injury in the Longa and Koizumi Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Mice.

However, with increasing occlusion time, we noticed an interesting trend in the hippocampus, where the dorsal and ventral hippocampus often lacked staining, suggesting ischemic injury, at earlier time points (8/18 and 9/18 respectively for all animals with 60 min MCAO via the Koizumi method, with thick filaments, analysed 4 h after reperfusion), yet tended to have little obvious hippocampal injury at 24 h (1/10 and 1/10 respectively for all animals with 60 min MCAO via the Koizumi method, with the thick filaments, after 24 h after reperfusion).

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