When the expression of PH-Tau is induced, correlating to later stages where PH-Tau becomes sarkosyl-insoluble, there is highly significant neuronal loss and astrocytosis in the hippocampus even as observed cognitive deficits are apparently alleviated and synaptic proteins are recovered.
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Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss.
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