Only highly enriched (enrichment over background ≥5-fold, pileup ≥25) and highly significant ( q -value < 0.01) peaks were shortlisted from the analysis, which yielded 1549 peaks in OVCAR3, 6589 peaks in PEO1 and 9412 peaks in OVCAR429. de novo Motif search was conducted by MEME-ChIP 54 using the peak center extended by 75 bp in both directions.
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GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.
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