A highly significant overlap was found with genes differentially expressed upon introduction of SS18-SSX with p values of 3.54E-22 and 1.77E-9 for induced and repressed genes, respectively ( Table S4 and S5 ) indicating that SS18-SSX induces a partial Wnt signature in C3H10T1/2 cells.
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The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma.
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